Population Pharmacokinetics of Tigecycline in Patients Treated With ECMO

Nanfang Hospital, Southern Medical University

Status: Unknown

Conditions: Tigecycline; Extracorporeal Membrane Oxygenation; Pharmacokinetics

Study type: Observational

Funder types: Other

Identifiers

NCT04724798

NFEC-2020-021

Details and patient eligibility

About

Tigecycline is a commonly used antibiotic in critically ill patients. The pharmacokinetics (PK) of tigecycline in intensive care unit (ICU) patients can be affected by severe pathophysiological changes so that standard dosing might not be adequate. At present, a number of studies have reported that ECMO will affect the PK of anti-infective drugs and lead to treatment failure. The purpose of this study was to describe the population PK of tigecycline in patients treated with ECMO and to evaluate the relationship between individual PK parameters and patient covariates.

Enrollment: 10 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• critically ill hospitalized males or nonpregnant females aged ≥18 years with severe infections which the treating clinician was treating with tigecycline.

Exclusion criteria

• People who had taken tigecycline in the past week
• People who were pregnant
• People who had coagulation dysfunction