Population PK of Antibiotics, Sedative and Analgesics, and Antiplatelet Drugs During ECMO

Gachon University Gil Medical Center

Status: Enrolling

Conditions: Extracorporeal Membrane Oxygenation; Pharmacokinetics

Treatments: Other: Residual blood

Study type: Observational

Funder types: Other

Identifiers

NCT05406492

GDIRB2019-228

Details and patient eligibility

About

The purpose of this study is to optimize the dosage regimen of drugs in patients during during Extracorporeal Membrane Oxygenation (ECMO) by population pharmacokinetic modeling.

Enrollment: 10 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who are taking levofloxacin, meropenem, vancomycin, cefepime, midalzolam, dexmedetomidine, propofol, clopidogrel, ticagrelor, or prasugrel while underdoing Extracorporeal Membrane Oxygenation

Exclusion criteria

• Pregnant women
• Receiving a therapy that can affect blood concentration due to a drug-drug interaction with levofloxacin, meropenem, vancomycin, cefepime, midalzolam, dexmedetomidine, propofol, clopidogrel, ticagrelor, or prasugrel

Trial design

10 participants in 1 patient group

Patients udergoing ECMO

Description:

Population who have been taking antibiotics or antiplatelets or sedatives/analgesics during Extracorporeal Membrane Oxygenation

Treatment:

Other: Residual blood