PORCINE XENOGRAFT OR MICROBIAL CELLULOSE IN THE TREATMENT OF PARTIAL THICKNESS BURNS

University Hospital, Linkoeping

Status: Completed

Conditions: Burn Second Degree; Burns; Burn Scar

Treatments: Other: microbial cellulose

Study type: Interventional

Funder types: Other

Identifiers

NCT04412759

MC-2015

Details and patient eligibility

About

The purpose of this study was to compare two wound dressing products for partial thickness burns in adults.

Full description

After being informed about the study, all patients that had given written informed consent underwent screening. If eligible study participants were randomized to be treated wih either the standard dressing of care; pigskin or a microbial cellulose. Dressing were applied within 72 hours after burn injury. Evaluation was done in an open manner due to the specific characteristics of the dressings. Study particpants were followed weekly until complete wound closure and after that evaluated at 6 and 12 months after injruy for burn scar outcome.

Enrollment: 26 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Study participants admitted within 72 hours of injury
• partial-thickness burns requiring a temporary skin cover
• written informed consent

Exclusion criteria

• severe coexisting cutaneous trauma
• chronic or current skin disease,
• severe cognitive dysfunction or psychiatric disorder
• pregnant or breast feeding women were excluded.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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26 participants in 2 patient groups

Porcine xenograft

No Intervention group

Description:

porcine xenograft derived from dermal porcine skin. Standard of care treatement for partila thickness burn at the specfic centre

Microbial cellulose

Experimental group

Description:

Novel dressing consisting of a biopolymer spun by the bacteria Acetobacter xylinum (later removed).

Treatment:

Other: microbial cellulose