Porous and Non-porous Bone Grafts in Intra-bony Periodontal Defects

Dr. D. Y. Patil Dental College & Hospital

Status and phase: Completed; Phase 3; Phase 2

Conditions: Periodontal Disease

Treatments: Drug: Porous variant of Bioactive Glass.; Drug: Non porous variant of Bioactive Glass.

Study type: Interventional

Funder types: Other

Identifiers

NCT02463006

DYPDCH/12/PG16

Details and patient eligibility

About

Till date, no study has been reported in the literature where porous bioactive glass was used for the management of periodontal osseous defects. In this context, the present study is designed to assess the efficacy of the porous variant of bioactive glass and compare with that of nonporous variant using cone beam computed tomography.

Full description

OBJECTIVES:

To evaluate clinically the periodontal healing with Porous variant of Bioactive Glass placed in the intra bony defects at an interval of 6 months. To evaluate clinically the periodontal healing with Non Porous variant of Bioactive Glass placed in the intra bony defects at an interval of 6 months. To evaluate the radiographic changes in the intra bony defect grafted with Porous variant of Bioactive Glass at baseline and an interval of 6 months. To evaluate the radiographic changes in the intra bony defect grafted with Non Porous variant of Bioactive Glass at baseline and an interval of 6 months. To compare clinically soft tissue healing for sites grafted with Porous variant of Bioactive Glass and sites grafted with Non Porous variant of Bioactive Glass in the treatment of periodontal intra bony defects at an interval of 6 months. To compare the radiographic changes for sites grafted with Porous variant and sites grafted with Non Porous of Bioactive Glass in the treatment of periodontal intra bony defects at an interval of 6 months.

Enrollment: 10 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• INCLUSION CRITERIA

  1. Age: 18-55 years.
  2. Probing Depth >5mm.

Exclusion criteria

• EXCLUSION CRITERIA

  1. History of periodontal treatment last six months.
  2. Bleeding disorders.
  3. Gross oral pathology.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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10 participants in 2 patient groups

porous bone graft group

Experimental group

Description:

Intervention: Flap surgery procedure with porous bone grafting (Periooglass)

Treatment:

Drug: Porous variant of Bioactive Glass.

Non-porous bone gaft group

Active Comparator group

Description:

Intervention: Flap surgery procedure with non-porous bone grafting (Novabone morsels)

Treatment:

Drug: Non porous variant of Bioactive Glass.