Portal Vein Pulsatility Flow in Pregnancy

University Hospital Basel

Status: Completed

Conditions: Pregnancy

Treatments: Other: ultrasound

Study type: Observational

Funder types: Other

Identifiers

NCT04429178

2020-00774 qu19Buddeberg;

Details and patient eligibility

About

This study is to investigate if portal vein pulsatility fraction can be measured in pregnancy and if it increases during the course of pregnancy as would be expected by the physiologic increase in blood volume that happens during pregnancy. Portal vein pulsatility fraction is measured in non-pregnant controls and in women in the 1st, 2nd and 3rd trimester of pregnancy.

Enrollment: 80 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Ability to give informed consent
• American Society of Anesthesiologists (ASA) Class I and II
• Singleton pregnancy during 1st, 2nd or 3rd trimester or healthy non-pregnant females of childbearing age as controls

Exclusion criteria

• Inability to give informed consent
• Multiple gestation
• Significant co-morbidities (e.g. cardiac abnormalities, cardiac dysfunction, arrhythmias, severe asthma, renal insufficiency)
• High risk pregnancies (e.g. pre-eclampsia, gestational hypertension, HELLP, gestational diabetes)
• Body-Mass-Index (BMI) < 18kg/m2 or >40kg/m2

Trial design

80 participants in 4 patient groups

women in the 1st trimester of pregnancy.

Treatment:

Other: ultrasound

women in the 2nd trimester of pregnancy.

Treatment:

Other: ultrasound

women in the 3rd trimester of pregnancy.

Treatment:

Other: ultrasound

non-pregnant women

Treatment:

Other: ultrasound