Portal Vein Pulsatility Index to Assess Fluid Intolerance

Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu

Status: Completed

Conditions: Venous Congestion

Treatments: Drug: Ringer's Lactate Crystalloid Solutions

Study type: Observational

Funder types: Other

Identifiers

NCT06440772

6066/21.02.2023

Details and patient eligibility

About

This study uses the portal vein pulsatility index (PVPI) to assess fluid intolerance amongst fluid responders.

Full description

This prospective observational study aims to use the portal vein pulsatility index (PVPI) to assess fluid intolerance in fluid responders. The investigators will enroll mechanically ventilated postoperative adult patients within 6 hours of ICU admission after cardiac surgery. Patients will undergo a Passive Leg Raising (PLR) test and Left Ventricular Outflow Tract (LVOT) recording using transthoracic echocardiography. The main objective is to predict fluid intolerance after a fluid challenge of 7 ml/kg Ringer Lactate over 10 minutes in initially tolerant fluid responders.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Informed consent.
• Mechanically ventilated patients within 6 hours after ICU admission following surgery who are considered for fluid administration to optimize haemodynamics.
• Sinus rhythm.

Exclusion criteria

• A condition known to interfere with portal vein flow assessment or interpretation (liver cirrhosis or chronic hepatic disease, suprahepatic or portal vein thrombosis).
• Any mechanical circulatory support.
• Cardiac transplant.
• Poor transthoracic echocardiographic window.

Trial design

50 participants in 1 patient group

Tolerant Fluid Responders

Description:

Patients who are both responsive and tolerant to fluid.

Treatment:

Drug: Ringer's Lactate Crystalloid Solutions