Portal Vein Resection in Pancreatic Neuroendocrine Tumours (PVNET)

NHS Foundation Trust

Status: Unknown

Conditions: Neuroendocrine Tumors; Pancreas Neoplasm

Treatments: Procedure: Portal vein resection / reconstruction

Study type: Observational

Funder types: Other

Identifiers

NCT04336839

11536

Details and patient eligibility

About

The limited evidence on the value of portal vein resection in patients with borderline resectable and/or locally advanced PanNENs is an incentive to carry out a retrospective multicentre study amongst centres with specific interest in the management of PanNENs and with experience on vascular reconstruction. Unlike previous studies on pancreatic cancer, it is more difficult to standardise the comparative parameters as the definition of borderline resectable disease has never been published for PanNENs. Similarly, different histological classifications make impossible to collect data exclusively on T3 tumours. Therefore, we aim to compare the short and long-term outcomes (including the impact of the histological depth of vascular invasion on survival) between patients undergoing standard PD and PD with portal vein resection for PanNENs, (regardless of T stage), by collecting and analysing retrospective data in this single centre study

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

All patients undergoing pancreaticoduodenectomy (Whipple's or Pylorus Preserving Pancreaticoduodenectomy) for sporadic PanNENs of the head of the pancreas of any stage (R0 or R1 resections) operated from 1st January 2007 up to 31st December 2016 inclusive.

Exclusion criteria

• Multiple Neuroendocrine Neoplasia (MEN) syndrome or other genetic background
• Age <18 years old
• Total pancreatectomy or different operation rather than PD
• R2 Resections