Post -Extubation Respiratory Failure

Cairo University (CU)

Status: Completed

Conditions: Respiratory Insufficiency

Treatments: Device: High flow nasal cannula

Study type: Interventional

Funder types: Other

Identifiers

NCT04441736

MS-313-2019

Details and patient eligibility

About

comparing high flow nasal cannula , conventional oxygen tharapy and non invasive ventilation post-extubation period for patients mechanically ventilated due to respiratory failure regarding re-intubation rate, ICU outcome & 28 days mortality

Full description

patients with respiratory failure either type I or type II planned for extubation will be divided into 3 groups post extubation :

Group I: will receive high flow nasal cannula giving oxygen 60 litres / minute flow group II: will receive nasal cannula up to 10 litres / minute group III: will receive non invasive ventilation

Data of the patients will be collected for 28 days post-extubation and analysed

Enrollment: 60 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• respiratory failure type I and Type II

Exclusion criteria

• Mechanical ventilation due to other cause such as disturbed conscious level or respiratory muscle weakness

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 3 patient groups, including a placebo group

High flow nasal cannula

Active Comparator group

Description:

A device of high flow nasal cannula giving 60 litres / min flow

Treatment:

Device: High flow nasal cannula

Conventional oxygen

Placebo Comparator group

Description:

Nasal cannula giving oxygen up to 10 litres / minute

Treatment:

Device: High flow nasal cannula

Non invasive ventilation

Active Comparator group

Description:

non invasive ventilation with IPAP and EPAP

Treatment:

Device: High flow nasal cannula