Positive Association of US-FLI With the Severity of CAD

Chongqing Medical University

Status: Enrolling

Conditions: SYNTAX Score; Coronary Artery Disease of Significant Bypass Graft; Ultrasonography; Metabolic Dysfunction-associated Fatty Liver Disease

Treatments: Other: Observational study without human intervention

Study type: Observational

Funder types: Other

Identifiers

NCT06541132

ChongqingM

Details and patient eligibility

About

As a multisystem disease, metabolic dysfunction-associated fatty liver disease (MAFLD) is closely linked to the onset and progression of coronary heart disease (CHD). Ultrasonographic fatty liver indicator (US-FLI) is a semi-quantitative tool for evaluating the degree of hepatic steatosis. Our study aims to explore the relationship between US-FLI based on MAFLD and the severity of CHD.

Full description

204 patients who had invasive coronary angiography performed between July 2022 and December 2023 at the cardiology department of the Second Affiliated Hospital of Chongqing Medical University were included in this study. Collect clinical information and abdominal ultrasound images from each patient. Hepatic steatosis which quantified by US-FLI was evaluated by the echo contrast between liver and kidney, posterior attenuation of ultrasound beam, areas of focal sparing, display of hepatic vessels, gallbladder wall and diaphragm. Fatty liver was diagnosed when US-FLI≥2. The severity of CHD was evaluated using the SYNTAX score (SS), and a total of 100 CHD patients were ultimately diagnosed. CHD patients were further divided into the low-risk group (SS ≤ 22) (54 cases) and the medium-high-risk group (SS≥23) (46 cases). Multivariate logistic regression model was used to assess the relationship between US-FLI and SS in patients with MAFLD. The receiver operating characteristic curve was used to determine the accuracy, sensitivity and specificity of US-FLI in predicting SS.

Enrollment: 190 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients older than 18 years old
• Patients underwent ICA due to chest pain, chest tightness or other reasons in our hospital from August 2022 to December 2023 were included in our study

Exclusion criteria

• Incomplete clinical data
• previous coronary stent implantation
• no abdominal ultrasound examination
• poor ultrasound image quality
• congenital heart disease
• tumor
• thyroid diseases and infectious diseases

Trial design

190 participants in 4 patient groups

Non-CAD group

Description:

non-coronary artery disease group

CAD group

Description:

coronary artery disease group

Treatment:

Other: Observational study without human intervention

SS≤22 group

Description:

SYNTAX score ≤22

SS≥23 group

Description:

SYNTAX score ≥23

Treatment:

Other: Observational study without human intervention