Positive End-expiratory Pressure and Alveolar Recruitment for One Lung Ventilation

Yonsei University

Status: Completed

Conditions: One Lung Ventilation

Treatments: Other: PEEP

Study type: Interventional

Funder types: Other

Identifiers

NCT01652612

4-2011-0301

Details and patient eligibility

About

Hypoxia frequently develops during one lung ventilation in the supine position.The objective of this article is to study the impact of preemptive alveolar recruitment and subsequent positive end expiratory pressure on arterial oxygenation and lung mechanics during one lung ventilation in the supine position in patients undergoing thoracic surgery .

Full description

outcome measures: respiratory parameters (Paw, Ppla, Compliance, Vd/Vt)and oxygenation parameters (PaO2, shunt fraction, Pa-AO2)

Enrollment: 99 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-II
• age: 20-75 years

Exclusion criteria

• moderate to severe impaired respiratory function,
• heart failure,
• patients' refusal

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Double Blind

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99 participants in 3 patient groups

Control

No Intervention group

Description:

zero PEEP

OLV strategy: PEEP

Experimental group

Description:

1. apply 8 cm H2O positive end expiratory pressure during one lung ventilation and until the end of surgery

Treatment:

Other: PEEP

OLV strategy: PEEP followed by AR

Experimental group

Description:

1. alveolar recruitment strategy before one lung ventilation 2. 8 cmH2O positive end expiratory pressure during one lung ventilation and until the end of surgery

Treatment:

Other: PEEP