Positron Emission Tomography of Infection and Vasculitis (PETU)

Turku University Hospital (TYKS)

Status: Completed

Conditions: Infection; Vasculitis

Treatments: Radiation: PET/CT

Study type: Observational

Funder types: Other

Identifiers

NCT01878721

14824

Details and patient eligibility

About

The purpose of this study is to evaluate the value of positron emission tomography/computed tomography in various inflammatory conditions caused by bacterial infection or vasculitis. Glucose analog FDG is sensitive to detect inflammation foci but we hypothesize that other imaging agents such as PK11195 and Ga-citrate may have added value in certain applications.

Full description

The purpose of this study is to evaluate the value of PET/CT in various inflammatory conditions caused by bacterial infection or vasculitis. Our aim is to:

1. investigate whether FDG (18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose) PET/CT and 68Ga-(Gallium-68) citrate PET/CT enable the early and accurate detection of metastatic infection foci in Staphylococcus aureus bacteremia.
2. study the usefulness of FDG PET/CT in detection of endovascular infection in bacteremia caused by Salmonella spp.
3. find an optimal FDG PET/CT protocol for detection of infectious endocarditis and metastatic infection foci related to endocarditis.
4. study the value of FDG PET/CT in the diagnosis of infection of pacemaker or implantable cardioverter defibrillator.
5. investigate the usefulness of FDG PET/CT, 68Ga-citrate PET/CT, and 11C- (carbon-11) translocator protein ligand (PK11195) PET/CT in diagnosis of vasculitis and in imaging of the magnitude of the vascular changes.

Enrollment: 117 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Adults with

• Staphylococcus aureus bacteremia or
• Salmonella spp. bacteremia or
• infective endocarditis or
• infection of pacemaker or implantable cardioverter defibrillator or
• vasculitis

Exclusion criteria

• underage, pregnant, breastfeeding, handicapped or prisoner

Trial design

117 participants in 5 patient groups

Staphylococcus aureus bacteremia

Description:

PET/CT in patients with Staphylococcus aureus bacteremia

Treatment:

Radiation: PET/CT

Salmonella spp. bacteremia

Description:

PET/CT in patients with Salmonella spp. bacteremia

Treatment:

Radiation: PET/CT

Endocarditis

Description:

PET/CT in patients with infective endocarditis

Treatment:

Radiation: PET/CT

Pacemaker infection

Description:

PET/CT in patients with pacemaker infection

Treatment:

Radiation: PET/CT

Vasculitis

Description:

PET/CT in patients with vasculitis

Treatment:

Radiation: PET/CT