Post Bariatric Surgery Acute Kidney Injury: Incidence and Risk Factors

Georgina Tharwat Abdelmasih

Status: Not yet enrolling

Conditions: Acute Kidney Injury; Bariatric Surgery

Study type: Observational

Funder types: Other

Identifiers

NCT06697743

Post bariatric surgery AKI

Details and patient eligibility

About

Bariatric surgery is the most effective means of inducing and maintaining sustained weight loss. Apart from the weight loss effect, bariatric surgery leads to the remission of chronic metabolic disorders such as type 2 diabetes (T2D) and hypertension . Recent studies have shown that bariatric surgery improves renal perfusion and glomerular function and reduces inflammatory markers which can lead to an improvement of microalbuminuria and proteinuria However, acute kidney injury (AKI) can complicate the postoperative course after bariatric surgery. The etiology of AKI after bariatric surgery can be multifactorial and complex in obese population . The preexisting factors such as diabetes, hypertension, and CKD in these patients can additionally worsen the renal insult during the postoperative period . Postoperative AKI is associated with increase morbidity and mortality especially in cases of severe AKI that requires dialysis support . Identifying the high-risk patients for development of postoperative AKI would prevent renal injury. Our aim was to study the incidence and etiology of postoperative AKI after bariatric surgery . Causes of post bariatric surgery AKI include . Pre renal causes :dehydration ( repeated vomiting and diarrhoea)which are common complications post bariatric surgery , haemorrhagic shock (from the site of anastomosis , ulcer ) , septic shock ( leakage , pneumonia) , hypotension and respiratory depression secondary to narcotic overdose. Rena causes: contract induced nephropathy after using CT scan guided drainage of intra abdominal collection post operative, Rhabdomylosis , drug induced nephropathy e.g :using of IV vancomycin for sepsis in ICU .. many causes can lead to AkI post bariatric surgery but the common two causes are dehydration and sepsis .

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

1. Inclusion criteria:

   1. Age more than 18 years old undergo bariatric surgery .
   2. BMI ≥30 : ( BMI = weight in kg / height in m²)

2. Exclusion criteria:

   1. previous kidney diseases(AKI , CKD) .
   2. patients unfit for surgery e.g ( comorbidities : CHD , LCF ) 3. Drugs : (ACE-I , ARBs, and NSAIDS)

Trial design

30 participants in 1 patient group

Patient undergo bariatric surgery

Description:

1. Inclusion criteria: 1. Age more than 18 years old undergo bariatric surgery . 2. BMI ≥30 : ( BMI = weight in kg / height in m²) 2. Exclusion criteria: 1. previous kidney diseases(AKI , CKD) . 2. patients unfit for surgery e.g ( comorbidities : CHD , LCF ) 3. Drugs : (ACE-I , ARBs, and NSAIDS)