Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine

The University of Texas System (UT)

Status and phase: Completed; Phase 4

Conditions: Analgesics; Morphine; Central Nervous System Depressants; Analgesics, Opioid; Physiological Effect of Drugs; Narcotics

Treatments: Drug: 3% 2-chloroprocaine and epidural morphine; Drug: 2% lidocaine with 1:200,000 epinephrine and epidural morphine

Study type: Interventional

Funder types: Other

Identifiers

NCT04369950

HSC-MS-19-0951

Details and patient eligibility

About

The purpose of this study is to show that the effect of 3% 2-chloroprocaine prior to epidural morphine administration will be not inferior to the effect of epidural 2% lidocaine with 1:200,000 epinephrine on total opioid use for 24h

Enrollment: 44 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• pregnant patients
• live singleton pregnancy

Exclusion criteria

• BMI >40
• obstructive sleep apnea
• drug abuse
• chronic pain
• chronic opioid use
• nonfunctioning epidural

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

44 participants in 2 patient groups

2 percent Lidocaine with epinephrine and epidural morphine

Active Comparator group

Treatment:

Drug: 2% lidocaine with 1:200,000 epinephrine and epidural morphine

3 percent 2-Chloroprocaine and epidural morphine

Experimental group

Treatment:

Drug: 3% 2-chloroprocaine and epidural morphine