Post Cond No Reflow

Civil Hospices of Lyon

Status: Completed

Conditions: Myocardial Reperfusion Injury

Treatments: Procedure: postconditioning

Study type: Interventional

Funder types: Other

Identifiers

NCT01208727

2008-504

Details and patient eligibility

About

After having shown that postconditioning allowed a significant 36% reduction of infarct size as assessed by blood levels of myocardial enzymes in acute myocardial patients, the investigators objective is to assess the effect of postconditioning in acute myocardial infarction (AMI) patients on microvascular obstruction lesions defined by cardiac MRI images.

Enrollment: 44 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients > 18 years old,
• Male or female,
• Presenting first myocardial infarction, with the beginning of pains < 12 hours,
• Requiring a revascularisation by primary angioplasty or " rescue " (after failure of thrombolysis) on IVA or RCA (not CA).
• Artery guilty with TIMI flow = 0

Exclusion criteria

• cardiac arrest before the angioplasty,
• Cardiogenic shock
• Occlusion of the artery circumflex responsible for the infarction
• Magnetic resonance imaging: contre indication

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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44 participants in 2 patient groups

Control

No Intervention group

Description:

22 controls patients without post conditionment

Intervention

Experimental group

Description:

22 posconditioned patients

Treatment:

Procedure: postconditioning