Post-conditioning to Reduce Infarct Size

Minneapolis Heart Institute Foundation

Status: Completed

Conditions: Myocardial Infarction

Treatments: Procedure: Post-conditioning

Study type: Interventional

Funder types: Other

Identifiers

NCT00755469

opt002

Details and patient eligibility

About

When angioplasty (PTCA) and stenting of the blood vessels of the heart is the treatment for a Heart Attack, there is damage to the heart muscle that is caused by the sudden opening of the blood vessels. This is called "reperfusion injury". The cell death is due to inflammation and the generation of free radicals.

The primary objective of this study is to determine if post-conditioning(four brief (30 second) PTCA balloon inflations) reduces damage to the heart muscle. This will be measured by heart enzyme tests-CK measurements- and by cardiac MRI.

Enrollment: 43 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 < 80
• Able to give informed consent
• 100% occlusion of a major epicardial vessel with TIMI 0 Flow

Exclusion criteria

• Significant collateral blood flow to the distal vasculature of the occluded vessel.
• Previous CABG
• Previous q-wave myocardial infarction in the same territory

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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43 participants in 1 patient group

1

Experimental group

Treatment:

Procedure: Post-conditioning