Post-COntrast 3D SE T1 Versus Coronal SE T1-WI MRI in Detecting Optic Neuritis (COCON)

Fondation Ophtalmologique Adolphe de Rothschild

Status: Completed

Conditions: Multiple Sclerosis; Optic Neuritis

Treatments: Diagnostic Test: Magnetic Resonance Imaging

Study type: Observational

Funder types: NETWORK

Identifiers

NCT04793087

CE_20200204_2_ALR

Details and patient eligibility

About

3D FLAIR, 3D T1 FAT SAT, coronal T2 and coronal T1 dixon sequences were usually used to assess visual deficits in MRI. Optic nerve examination is preferably performed using a coronal T2 sequence in order to detect a hypersignal suggestive of inflammation whereas brain examination is preferably performed using a 3D T1 sequence to highlight signs of spatial dissemination and lesions suggestive of multiple slerosis (MS). No study has yet investigated the detection capabilities of 3D T1 for the detection of optic nerve inflammation. The objective of this retrospective study was to determine whether a single 3D T1 sequence allows simultaneous exploration of the optic nerve and the brain for the positive diagnosis of optic neuropathy and/or MS.

Enrollment: 1,200 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years
• Decrease in visual acuity explored in MRI between january 2018 and january 2020

Exclusion criteria

• Past history of episode of Optic neuritis