Post-extubation Assessment of Laryngeal Symptoms and Severity (PALSS)

Johns Hopkins University

Status: Completed

Conditions: Intubation, Intratracheal; Mechanical Ventilation Complication; Critical Illness; Complication of Ventilation Therapy

Treatments: Diagnostic Test: laryngoscopy

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT03726086

IRB00151643

R01NR017433-01A1 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The goal of this study is to learn more about voice and airway problems that patients experience during and after the time patients have an oral endotracheal tube in patients' airway to help patients breathe while receiving mechanical ventilation in an intensive care unit (ICU).

Enrollment: 365 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ≥18 years old
• Required mechanical ventilation via an oral endotracheal tube
• Anticipated intubation ≥8 hours

Exclusion criteria

• Pre-existing dysphonia, dysphagia
• Pre-existing central nervous system, neuromuscular, or connective tissue disease
• Prior tracheotomy and/or tracheotomy placed prior to enrollment
• History of major thoracic surgery (e.g., sternotomy, thoracotomy) prior to the current admission
• Head and/or neck disease
• Head and/or neck surgery other than tonsillectomy
• Known or suspected anatomical abnormalities or pre-intubation trauma of the oral cavity, pharynx, larynx, or esophagus
• Unlikely to be extubated (i.e., expected death)