Post Infarction Exercise Effects on Myocardial Function Assessed by 2D Strain Ultrasound (TrainStrain)

Centre Hospitalier Universitaire de Nīmes

Status: Completed

Conditions: Myocardial Infarction

Treatments: Other: Cardiac training program

Study type: Interventional

Funder types: Other

Identifiers

NCT02932696

NIMAO/2016-06/AD-01

Details and patient eligibility

About

The main goal of our project is to study and describe the effect of exercise training on systolic and diastolic myocardial function assessed by 2D ultrasound strain after myocardial infarction.

Our working hypothesis is that the intrinsic myocardial contractility and relaxation assessed by global longitudinal strain in phase II (or 2D strain) during post-infarction exercise training will be improved compared to baseline values as well as compared to values in a no-training group. Should this hypothesis prove true, it would help explain the improvements in functional capacity observed during the post-infarction period and after exercise training.

Enrollment: 65 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The patient must have given his/her informed and signed consent
• The patient must be insured or beneficiary of a health insurance plan
• The patient is available for 4 months of follow-up
• The patient had a first myocardial infarction episode (within the past 3 months) requiring medical treatment or revascularisation (e.g. balloon angioplasty) or aortocoronary bypass

Exclusion criteria

• The patient is simultaneously participating in (or has participated in the past 3 months) another interventional study
• The patient is in an exclusion period determined by a previous study
• The patient is under judicial protection or under guardianship
• It is impossible to correctly inform the patient or the patient refuses to sign the consent
• The patient is pregnant, parturient, or breastfeeding
• Contra indication for exercise training
• Valve prosthesis
• Severe valvular disease
• Pacemaker
• Heart transplant
• Non sinus rhythm

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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65 participants in 2 patient groups

Exercise training

Experimental group

Description:

Patients in this arm were encouraged to participate in an exercise training program, and they accepted to do so. Intervention: Cardiac training program

Treatment:

Other: Cardiac training program

No exercise training

No Intervention group

Description:

Patients in this arm were encouraged to participate in an exercise training program, and they refused to do so.