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Post-Infectious Irritable Bowel Syndrome (PI-IBS)

C

Catholic University (KU) of Leuven

Status

Completed

Conditions

Irritable Bowel Syndrome With Diarrhea

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

Purpose:

  • identification of factors predisposing for Post-Infectious Irritable Bowel Syndrome (PI-IBS) development after an episode of traveler's diarrhea
  • identification of systemic (serum) and local (biopsy) changes in infectious and immunological activity during infection and correlation with Irritable Bowel Syndrome (IBS) symptoms, persisting after traveler's diarrhea

Design:

  • 4 study visits: before traveling, 2 weeks after traveling, 6 months after traveling, 12 months after traveling
  • at each study visit following investigations: blood collection, stool collection, questionnaires, rectal biopsy

Enrollment

131 patients

Sex

All

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • traveling to South-America, Africa, South-East Asia
  • 18-70 years
  • traveling for 1-10 weeks

Exclusion criteria

  • Chronic diarrhea
  • Pregnant
  • Colitis Ulcerosa
  • Morbus Chrohn
  • IBS
  • Coeliakie
  • Gastrointestinal malabsorption
  • microscopic colitis
  • diverticulitis
  • immune deficiency
  • use of antibiotics/corticosteroids 2 weeks before travelling

Trial design

131 participants in 1 patient group

travelers to tropical destinations

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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