Post-Intensive Care Syndrome and Associated Symptom Burden Among Danish ICU Survivors (PICAS-DK)

Zealand University Hospital

Status: Begins enrollment in 3 months

Conditions: Symptom Burden; Post-Intensive Care Syndrome (PICS); Intensive Care Unit (ICU) Patients

Study type: Observational

Funder types: Other

Identifiers

NCT07373561

ID not known yet

Details and patient eligibility

About

The study aims to estimate the prevalence of post-intensive care syndrome (PICS) 12 months after ICU admission among adult ICU survivors in Denmark and to describe how this prevalence is distributed across the physical, cognitive, and mental health domains. By conducting follow-up assessments at 3, 6, and 12 months post-discharge, the study further seeks to determine the prevalence of PICS at each time point, characterise its temporal trajectory, and explore patients' symptom burden over time.

Research question

• What is the prevalence of PICS and its specific components (physical, cognitive, and mental health domains) among ICU survivors 12 months after ICU admission?
• How do the components of PICS evolve during the follow-up period (trajectory)?
• What risk factors are associated with the development of PICS in ICU survivors?
• Are there differences in PICS prevalence based on demographic or clinical characteristics (e.g., age, comorbidities, ICU length of stay)?

The hypothesis is that the prevalence of post-intensive care syndrome (PICS) in a Danish cohort of adult ICU survivors at 12 months will be approximately one third, defined as impairment in at least one of the three PICS domains (physical, cognitive, or mental health), measured using validated instruments with pre-specified cut-offs.

Enrollment: 800 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients ≥ 18 years of age
• Admitted to the intensive care unit for ≥48 hours
• Acutely admitted to the intensive care unit

Exclusion criteria

• Patients with limited treatment
• Foreign patients
• Pregnant women
• Patient with impaired cognitive function (e.g. dementia, intellectual disability)
• Patient without Danish citizenship
• Patient with limited proficiency in the Danish language

Trial design

800 participants in 1 patient group

ICU patients

Description:

This study investigates ICU survivor patients in Denmark and aim to estimate the prevalence of post-intensive care syndrome within this group. There are three different follow-up times.