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Post-neurosurgical Respiratory Muscle Dysfunction

B

Beijing Sanbo Brain Hospital

Status

Enrolling

Conditions

Diaphragm Issues
Neurosurgery
Pulmonary Complication

Treatments

Diagnostic Test: Maximum inspiratory/Expiratory manoeuvre for patients can follow the order

Study type

Observational

Funder types

Other

Identifiers

NCT05951114
HP2023-28-508001

Details and patient eligibility

About

Respiratory muscle dysfunction may contribute to the development of postoperative pulmonary complications. However, it prevalence in patients receiving neurosurgery is largely unknown. Therefore, in present study, respiratory muscle function (measured by the ultrasound) and their correlation with the post-operative pulmonary complications will be analyzed.

Full description

Postoperative pulmonary complications is common in patients receiving neurosurgery, and is associated with hospitalization cost and mortality. Respiratory muscle dysfunction is an important cause postoperative pulmonary complications, however, it's prevalence in patients receiving neurosurgery is unclear.

The diaphragm and abdominal expiratory muscles are the main inspiratory and expiratory driving muscles. Ultrasound can assess the function and morphology of these muscles invasively and in realtime. Studies has demonstrated their feasibility and repeatability in realtime monitoring of respiratory muscles.

In this study, our primary aim is to assess the respiratory muscle function after neurosurgery, and the correlation between diaphragm and expiratory muscle function. Our secondary aims including the correlation between the brain injury and the respiratory muscle function, and the impact of post-operative respiratory muscle dysfunction on the pulmonary complications.

Enrollment

100 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Informed consent
  • First elective operation during hospitalization
  • ASA<3

Exclusion criteria

  • Brain stem and spinal spine lesions
  • Preoperative chest imaging findings were abnormal
  • Mechanical ventilation was required before surgery
  • Clinical or radiological evidence of preoperative misaspiration
  • History of neurosurgery in the last 6 months
  • A history of neuromuscular disease
  • BMI≥35kg/m2
  • Pregnant women
  • Skin lesions detected by ultrasound

Trial design

100 participants in 2 patient groups

Patients with diaphragm weakness
Description:
Diaphragm weakness will be defined as thickening fraction \<=20 % at the time of extubation
Treatment:
Diagnostic Test: Maximum inspiratory/Expiratory manoeuvre for patients can follow the order
Patients without diaphragm weakness
Description:
Diaphragm thickening fraction \>20 % at the time of extubation
Treatment:
Diagnostic Test: Maximum inspiratory/Expiratory manoeuvre for patients can follow the order

Trial contacts and locations

1

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Central trial contact

Zhonghua Shi, PhD

Data sourced from clinicaltrials.gov

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