Post-neurosurgical Respiratory Muscle Dysfunction

Beijing Sanbo Brain Hospital

Status: Enrolling

Conditions: Diaphragm Issues; Neurosurgery; Pulmonary Complication

Treatments: Diagnostic Test: Maximum inspiratory/Expiratory manoeuvre for patients can follow the order

Study type: Observational

Funder types: Other

Identifiers

NCT05951114

HP2023-28-508001

Details and patient eligibility

About

Respiratory muscle dysfunction may contribute to the development of postoperative pulmonary complications. However, it prevalence in patients receiving neurosurgery is largely unknown. Therefore, in present study, respiratory muscle function (measured by the ultrasound) and their correlation with the post-operative pulmonary complications will be analyzed.

Full description

Postoperative pulmonary complications is common in patients receiving neurosurgery, and is associated with hospitalization cost and mortality. Respiratory muscle dysfunction is an important cause postoperative pulmonary complications, however, it's prevalence in patients receiving neurosurgery is unclear.

The diaphragm and abdominal expiratory muscles are the main inspiratory and expiratory driving muscles. Ultrasound can assess the function and morphology of these muscles invasively and in realtime. Studies has demonstrated their feasibility and repeatability in realtime monitoring of respiratory muscles.

In this study, our primary aim is to assess the respiratory muscle function after neurosurgery, and the correlation between diaphragm and expiratory muscle function. Our secondary aims including the correlation between the brain injury and the respiratory muscle function, and the impact of post-operative respiratory muscle dysfunction on the pulmonary complications.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Informed consent
• First elective operation during hospitalization
• ASA<3

Exclusion criteria

• Brain stem and spinal spine lesions
• Preoperative chest imaging findings were abnormal
• Mechanical ventilation was required before surgery
• Clinical or radiological evidence of preoperative misaspiration
• History of neurosurgery in the last 6 months
• A history of neuromuscular disease
• BMI≥35kg/m2
• Pregnant women
• Skin lesions detected by ultrasound

Trial design

100 participants in 2 patient groups

Patients with diaphragm weakness

Description:

Diaphragm weakness will be defined as thickening fraction \<=20 % at the time of extubation

Treatment:

Diagnostic Test: Maximum inspiratory/Expiratory manoeuvre for patients can follow the order

Patients without diaphragm weakness

Description:

Diaphragm thickening fraction \>20 % at the time of extubation

Treatment:

Diagnostic Test: Maximum inspiratory/Expiratory manoeuvre for patients can follow the order