Post-operative Analgesic Effects of Dexamethasone Added to Bupivacaine in Transversusabdominis Plane (TAP) Block

Assiut University

Status and phase: Completed; Phase 3; Phase 2

Conditions: Postoperative Analgesia

Treatments: Drug: Bupivacaine; Drug: Dexamethasone

Study type: Interventional

Funder types: Other

Identifiers

NCT03863977

IRB:17100670

Details and patient eligibility

About

To compare the postoperative analgesic effect of two doses of dexamethasone added to bupivacaine in ultrasound-guided TAP block for inguinal hernia repair.

Full description

The transverses abdominis plane block (TAP block) is a regional anesthesia technique that provides analgesia following abdominal surgery . The TAP block significantly reduces pain after open inguinal hernia repair, regardless of whether it is used as a primary anesthesia technique or as a complement to general anesthesia, spinal or local anesthesia .

The investigators designed this study to compare the postoperative analgesic effect of two doses of dexamethasone( 4 mg and 8 mg ) added to bupivacaine in ultrasound-guided TAP block for inguinal hernia repair.

Enrollment: 90 patients

Sex: Male

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients' age from 18 to 60 years old,
• physical status ASA I-II (by the American Society of Anesthesiologists),
• Elective unilateral open inguinal hernia repair,
• Under spinal anesthesia

Exclusion criteria

• age < 18 or > 60,
• American society of anesthesiologist (ASA)class III-IV,
• known allergy to amino amide local anesthetics,
• skin infection and diseases at site of injection.
• coagulation disorders,
• patients with body mass index (BMI) > 35 kg/m2,
• scrotal hernias,

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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90 participants in 3 patient groups

Dex4 group

Active Comparator group

Description:

After the surgery, the patients in this group will receive 4 mg dexamethasone added to 1mg/kg of 0.5% bupivacaine in the TAP block.

Treatment:

Drug: Dexamethasone

Drug: Bupivacaine

Dex8 group

Active Comparator group

Description:

After the surgery, the patients in this group will receive 8 mg dexamethasone added to 1mg/kg of 0.5% bupivacaine in the TAP block.

Treatment:

Drug: Dexamethasone

Drug: Bupivacaine

control group

Active Comparator group

Description:

After the surgery, the patients in this group will 1mg/kg of 0.5% bupivacaine in the TAP block.

Treatment:

Drug: Bupivacaine