Post Operative Pain Control: Morphine vs Fentanyl

Catholic University of the Sacred Heart

Status: Completed

Conditions: Post Operative Analgesia

Treatments: Drug: Morphine; Drug: Fentanyl

Study type: Interventional

Funder types: Other

Identifiers

NCT02146638

MFN-6932-AS

Details and patient eligibility

About

Aim of this study is to compare benefits and disadvantages in using continuous infusion of morphine or fentanyl for post operative analgesia.

Enrollment: 60 patients

Sex: Female

Ages: 35 to 59 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA 1 or 2 patients
• undergoing major gynaecological surgery

Exclusion criteria

• age > 60 years
• obesity (BMI>30 Kg/m2)
• cardiac and respiratory diseases
• renal impairment
• liver disorders
• allergies to any drug used in the study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Morphine

Active Comparator group

Description:

Patients received morphine 0.02 mg/Kg/h infused at 2 ml/h for 24 hours. The infusion contained morphine and saline.

Treatment:

Drug: Morphine

Fentanyl

Experimental group

Description:

Patients received Fentanyl 0.3 mcg/Kg/h infused at 2 ml/h for 24 hours. The infusion contained morphine and saline.

Treatment:

Drug: Fentanyl