Post Operative Shivering Following Anesthesia

Sohag University

Status: Not yet enrolling

Conditions: Shivering, Spinal Anesthesia

Treatments: Drug: Mg (magnesium sulfate); Drug: Ondansetron 8 mg; Drug: Dexmedetomidin

Study type: Interventional

Funder types: Other

Identifiers

NCT07377903

Soh_med__25_12_10MS

Details and patient eligibility

About

The aim of this study is to compare the efficacy of magnesium sulphate, ondansetron, and dexmedetomidine in managing post-spinal anesthesia shivering. The primary aim is the time to cessation of shivering after drug administration, while secondary aim include hemodynamic parameters (heart rate, blood pressure, SpO₂ ) and the recurrence of shivering

Full description

This is a randomized double blinded study including patients undergoing surgery under spinal anesthesia. Patients will be randomly allocated into three groups to receive magnesium sulphate, ondansetron, or dexmedetomidine for the treatment of post-spinal anesthesia shivering. The time to cessation of shivering, hemodynamic parameters, and recurrence of shivering will be recorded.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age from 18 to 45 years.
• Both sexes.
• American Society of Anesthesiologists physical status I, II
• Scheduled for elective lower abdominal or lower limb surgeries under spinal anesthesia

Exclusion criteria

• Patients with known allergy to study drugs.
• Patients with baseline body temperature outside the normal range (36-37.5°C).
• History of thermoregulatory disorders, thyroid dysfunction, or neurological diseases.
• Patients receive sedatives, antipsychotics, or antidepressants.
• Patients require intraoperative conversion to general anesthesia.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 3 patient groups

Mg sulphate group

Experimental group

Description:

50 mg/kg magnesium sulphate diluted in 100 mL of normal saline.

Treatment:

Drug: Mg (magnesium sulfate)

dexmedetomidine group

Experimental group

Treatment:

Drug: Dexmedetomidin

ondansetron group

Experimental group

Treatment:

Drug: Ondansetron 8 mg