Post-Operative Use of Salt Poor Albumin Solution in Resuscitation of Orthotopic Liver Transplant

McGill University

Status: Unknown

Conditions: Liver Transplantation

Treatments: Drug: Albumin infusion (25% albumin)

Study type: Interventional

Funder types: Other

Identifiers

NCT00842803

SDR-08-030

Details and patient eligibility

About

The purpose of the study is to examine if outcome after liver transplantation is improved by using albumin infusion post-transplantation.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 years or older
• Canadian Transplant status 1 or 2
• Patients at the Royal Victoria Hospital, Montreal, Canada

Exclusion criteria

• Emergency liver transplant (canadian transplant status 3 or 4)
• patients who have received more than 300cc of albumin within 48 hours prior to transplant
• patients who underwent previous solid organ transplant
• multi-organs transplant recipients
• patients who had previous adverse reaction to human albumin solution
• patients who have religious restriction to receiving human blood products.
• patients or surrogate unable to give consent to the study

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Control Group

No Intervention group

Description:

Patients in this group will not be allowed albumin or any other colloids fluid for the first 7 days post-operative

Albumin group

Experimental group

Description:

Patients in this arm will receive albumin infusions 3 times a day for the first 7 days post-operative

Treatment:

Drug: Albumin infusion (25% albumin)