Post-Pregnancy Cardio Trial (PPC1)

Charité University Medicine Berlin

Status: Completed

Conditions: Preeclampsia

Study type: Observational

Funder types: Other

Identifiers

NCT03313063

PPC1

Details and patient eligibility

About

Preeclampsia is a systemic pregnancy disorder and is associated with an increased cardiovascular risk later in life. This study will characterize myocardial tissue in patients after preeclampsia compared to controls and investigate potential functional and structural changes in the heart of preeclamptic women primarily with two methods: cardiovascular magnetic resonance imaging and echocardiography. A comparison between these two methods, where appropriate, is also envisaged.

Enrollment: 47 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• postpartal window: 0.5 - 20 years
• cases: diagnosis of preeclampsia during the index pregnancy
• controls: age and BMI matched

Exclusion criteria

• metal implants
• kidney insufficiency (GFR < 30 ml/min/)
• claustrophobia
• contrast medium allergy
• current pregnancy/ lactation
• chronic hypertension (> 140/90)
• diagnosis of previous cardiovascular disease
• body weight over 120 kg
• big tattoos in thorax area

Trial design

47 participants in 2 patient groups

PE

Description:

Women with a history or preeclampsia, between 18 - 50 years of age, 0.5 - 20 years postpartum

Control

Description:

Age-matched women without any birth complications, between 18 - 50 years of age, 0.5 - 20 years postpartum