Post-stroke Cognitive Impairment (CogStroke)

Roza Umarova

Status: Active, not recruiting

Conditions: First-ever Ischemic Stroke; Cognitive Performance

Study type: Observational

Funder types: Other

Identifiers

NCT05653141

Studien-Nr. 4599

Details and patient eligibility

About

Present study aims to track the post-stroke cognitive trajectories and to investigate its inter-individual variability.

Full description

The study aim is to establish a model capturing patients' inter-individual variability in susceptibility to stroke damage to predict stroke-induced cognitive trajectories. This is a prospective longitudinal observational national monocentric study for 6 years (recruitment during the first 3 years). The investigators perform comprehensive neuropsychological testing in i) acute stroke phase (0-10 days post-stroke), ii) sub-acute stroke phase (3 months post-stroke), and iii) chronic stroke phase (12 months and 3 years post-stroke). At each time point, cognitive performances as well as clinical and functional status will be assessed. Furthermore, the investigators will assess the proxies of cognitive reserve and the level of post-stroke physical activity.

Enrollment: 335 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥18 years old
• First-ever anterior circulation ischemic stroke confirmed by routine MRI
• Time of enrollment: ≤ 10 days from stroke onset.

Exclusion criteria

• Previous stroke anamnestic or based on clinical imaging
• Additional stroke in posterior circulation
• Conditions that preclude the cognitive testing (e.g. delirium, intubation, reduced vigilance
• Neurological or psychiatric conditions that preclude the data interpretation (e.g. pre-stroke dementia, schizophrenia, brain tumor, regular intake of benzodiazepine, depression)
• MRI contraindication
• Native language other than German, French or Italian

Trial design

335 participants in 1 patient group

Stroke patients

Description:

Adults with first-ever anterior circulation stroke