Post Stroke Psychological Distress (POSTPSYDIS)

Charité University Medicine Berlin

Status: Completed

Conditions: Stroke

Study type: Observational

Funder types: Other

Identifiers

NCT01187342

POSTPSYDIS

4-026-08

Details and patient eligibility

About

Neuro-psychological, cognitive and biochemical assessment matched with MR-Imaging in acute and chronic poststroke conditions.

Full description

The study design relates to affective symptomatology, particularly poststroke depression and posttraumatic stress symptoms as well as to cognitive decline due to stress-related hypercortisolemia in the early phase after stroke. Extended MRI studies including a functional connectivity (fc-MRI) paradigm have been incorporated to study on subacute midbrain neurodegeneration as a possible morphological correlate of functional and clinical findings.

Enrollment: 84 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Stroke in MCA/AchA territory of striato-capsular (at least 125mm³) or non-striatal (10-100cm³) involvement
• MR-imaging can be conducted 24-48 hours of onset
• preserved communication skills

Exclusion criteria

• Patients with psychiatric conditions or medication in the last 4 weeks
• severe medical conditions
• limited prognosis

Trial design

84 participants in 2 patient groups

Non-striatal lesion group

Description:

acute ischemic Stroke in MCA territory of 10-100 cm³ with sparing of striatocapsular structures

Striatal lesion group

Description:

acute ischemic stroke in MCA/AchA territory with involvement of at least 125 mm³ of striatocapsular structures