Post-thrombotic Syndrome After Deep Venous Thrombosis (DVT) in Patients Treated According to the NOPHO ALL2008 Protocol

Aarhus University Hospital

Status: Completed

Conditions: Post Thrombotic Syndrome; Acute Lymphoblastic Leukemia

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT04825548

PTS-NOPHOALL2008

Details and patient eligibility

About

Acute lymphoblastic leukemia (ALL) is the most common malignant disease in childhood. Today more than 90% of children and 75% of adults (18-45 years) survive ALL. The enzyme Asparaginase (Asp) is an indispensable part of the multiagent treatment of ALL.

Treatment related severe acute toxicities are common. Especially in teenagers and adults, thromboembolism is one of the most common acute toxicities and may result in post thrombotic syndrome (PTS) or pulmonary hypertension. The knowledge about these late effects is limited, including for ALL patients.

Enrollment: 27 patients

Sex: All

Ages: 1+ year old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Treated on the ALL2008 protocol for ALL. Had a DVT on treatment.

Exclusion criteria

• Death