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Post-Traumatic Stress Disorder (PTSD) and Seroquel

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Cambridge Health Alliance

Status

Completed

Conditions

Post-Traumatic Stress Disorder

Treatments

Drug: Seroquel

Study type

Interventional

Funder types

Other

Identifiers

NCT01066156
2009-P-001664

Details and patient eligibility

About

This 8 weeks study will investigate therapeutic responses to Seroquel pharmacotherapy in PTSD.

Full description

An initial telephone interview will be conducted to determine if potential subjects meet the basic study requirements. If no obvious counterindications are present, subjects will be scheduled for a screening visit. After briefing the subjects on the reasons for the research, they will be given an opportunity to read the Informed Consent Form, approved by the Cambridge Health Alliance Institutional ReviewBoard, and to ask questions prior to signing it. Subjects will be given a copy of the signed Consent Form. Each subject will complete a standardized interview schedule designed to obtain personal and background data along with psychodiagnostic and psychometric evaluations. An open-label treatment will be utilized for all patients. Seroquel tablets will be flexibly dosed and begun at a target dose of 25 mg per day and taken over an 8 week period.

Enrollment

34 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Provision of written informed consent
  • Fluency in English
  • A diagnosis of PTSD
  • No pregnancy
  • Right-handedness

Exclusion criteria

  • Pregnancy or lactation
  • Any cognitive impairment that precludes informed consent
  • Known intolerance or lack of response to Seroquel
  • Previous enrollment or randomization of treatment in the present study
  • Participation in another drug trial within 4 weeks prior enrollment into this study
  • Patients with Diabetes Mellitus
  • History of allergic reaction or hypersensitivity to Seroquel
  • Contraindications to magnetic resonance imaging
  • Treatment with an effective medication for PTSD

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

34 participants in 1 patient group

Seroquel
Experimental group
Description:
This study will investigate therapeutic responses to Seroquel pharmacotherapy in PTSD
Treatment:
Drug: Seroquel

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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