Postamputation Pain: Peripheral Mechanisms

Danish Pain Research Center

Status: Completed

Conditions: Amputation, Traumatic; Nerve Block; Neuropathic Pain; Phantom Limb Pain; Stump Pain

Treatments: Device: Lidocaine; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT03317600

Nerveblock2017

Details and patient eligibility

About

Stump and phantom pain after amputation are common, but the responsible mechanisms are still not clarified. It has been suggested that phantom limb pain can be reduced by regional anaesthesia and in several recent studies, pain was reduced following intrathecal and intraforaminal blocks. In this study, the investigators want to investigate if spontaneous and evoked pain in amputees will be relieved by regional nerve blocks involving the damaged nerves.

Enrollment: 12 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Amputees with chronic amputation pain (stump or phantom pain) 3 or above on NRS (numerical ratio scale).

Exclusion criteria

• Severe somatic or psychiatric diseases
• Other peripheral neuropathy
• Lack of ability to cooperate to the clinical examination
• Allergy to Lidocaine or similar analgetics

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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12 participants in 2 patient groups, including a placebo group

Lidocaine block

Active Comparator group

Treatment:

Device: Lidocaine

Isotonic saline block

Placebo Comparator group

Treatment:

Drug: Placebo