Postcapillary Blood Gas Analysis in Wedge Position (Wedge-BGA)

A

Ayham Daher

Status

Enrolling

Conditions

Pulmonary Hypertension

Treatments

Diagnostic Test: Blood gas analysis

Study type

Observational

Funder types

Other

Identifiers

NCT04993612
21-063

Details and patient eligibility

About

If pulmonary hypertension is suspected, a right heart catheterization is usually performed to confirm or rule out the diagnosis. As part of this examination, blood samples are taken from various locations as standard and blood gas analyses are performed. One of the most important measurements during the right heart catheterization is the measurement of the pulmonary arterial occlusion pressure by the so-called wedge maneuver. To measure this value, the catheter with inflated balloon must be advanced into the pulmonary vessels until the "wedge" position is reached, i.e. the balloon completely occludes a branch of the pulmonary artery. In this study, the investigators want to characterize patients with pulmonary hypertension of different causes in more detail. To do that, two blood samples (totaling approximately 4 mL of blood, one sample directly after occlusion and the other one two minutes later) will be drawn during the right heart catheterization from the above-mentioned "wedge" position", behind the inflated balloon, and blood gas analyses will be performed on these samples. In addition, various clinical parameters (comorbidities, etc.) will be recorded by means of clinical questionnaires. Follow-up data will be analyzed and correlations with the aforementioned blood gas analyses will be examined. The results of the study will be used to more precisely characterize the still vague concept of secondary pulmonary hypertension. This could help to develop new therapeutic strategies in some subgroups in the future.

Enrollment

100 estimated patients

Sex

All

Ages

18 to 99 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients who have a clearly defined indication for Right heart catheterization.
  • Age > 18 years
  • Informed consent for participation in the study will sign

Exclusion criteria

  • Individuals who are not fully capable of giving consent and understanding the nature, significance, and scope of the study
  • Pregnancy and lactation

Trial design

100 participants in 6 patient groups

No pulmonary Hypertension
Treatment:
Diagnostic Test: Blood gas analysis
pulmonary Hypertension Group 1
Treatment:
Diagnostic Test: Blood gas analysis
pulmonary Hypertension Group 2
Treatment:
Diagnostic Test: Blood gas analysis
pulmonary Hypertension Group 3
Treatment:
Diagnostic Test: Blood gas analysis
pulmonary Hypertension Group 4
Treatment:
Diagnostic Test: Blood gas analysis
pulmonary Hypertension Group 5
Treatment:
Diagnostic Test: Blood gas analysis

Trial contacts and locations

0

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location

Resources

© Copyright 2024 Veeva Systems