Postconditioning in the Treatment of Acute ST-segment Elevation Myocardial Infarction (POSTCON)

Rigshospitalet

Status and phase: Completed; Phase 4

Conditions: ST-segment Myocardial Infarction

Treatments: Procedure: Standard primary PCI; Procedure: Mechanical postconditioning

Study type: Interventional

Funder types: Other

Identifiers

NCT00507156

KF 01 326257

Details and patient eligibility

About

Standard treatment of patients with acute ST-segment elevation myocardial infarction consist of acute re-opening of the occluded coronary artery (primary PCI). Despite successful treatment of the epicardial vessel reperfusion is sometimes inadequate leading to large final infarct sizes. This phenomenon is known as the reperfusion injury. Several animal studies have indicated that graded re-opening of the artery may limit tissue damage. Generally this is referred to as mechanical postconditioning.

The study investigates the effect on final infarct size evaluated by magnetic resonance scan of postconditioning of ST-segment elevation myocardial infarctions. Mechanical postconditioning is performed by means of several balloon inflations in the injured vessel following its acute re-opening.

Full description

Please see above

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients more than 18 years
• STEMI < 12 hours
• TIMI 0-1 in infarct related artery

Exclusion criteria

• Multivessel disease (stenoses in non-infarct related arteries >70%)
• Cardiogenic shock
• Left main occlusions
• Lesions that cannot be treated with stents
• Previous CABG
• Pregnancy
• Severe renal insufficiency
• Previous extensive Q-wave infarction
• LBBB

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

200 participants in 2 patient groups

Mek postcon

Experimental group

Description:

Re-opening of the infarcted coronary artery by several balloon inflations separated by reperfusion of the vessel.

Treatment:

Procedure: Mechanical postconditioning

Standard treatment

Active Comparator group

Description:

Standard treatment (primary PCI)

Treatment:

Procedure: Standard primary PCI