Posterior Circulation ASTRAL Prognostic Score

University of Thessaly

Status: Active, not recruiting

Conditions: Posterior Circulation Brain Infarction; Stroke Acute; Stroke Ischemic; Risk Score

Treatments: Diagnostic Test: ASTRAL prognostic score

Study type: Observational

Funder types: Other

Identifiers

NCT05906420

pc-ASTRAL

Details and patient eligibility

About

The goal of this study is to develop a prognostic score for ischemic posterior circulation strokes, based on our previous work on with the ASTRAL scores (Acute STroke Registry and Analysis of Lausanne) on overall stroke prognosis, intracranial occlusion, recanalization and stroke recurrences. The main question it aims to answer is the modified Rankin score in 3 months after the event.

Participants will be patients with acute ischemic stroke of the posterior circulation with mRS priot to event <3. All the data will be collected retrospectively from patients included in the ASTRAL registry between January 2003 and December 2021. The ASTRAL registry will be used as the derivation cohort of the score. Demographics, acute glucose, NIHSS score and acute imaging of each participant will be used from the derivation cohort in order to create an integer-based prognostic score. After internal validation, we plan to validate the score in external stroke registries to show its validity.

Enrollment: 2,000 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Isolated posterior circulation strokes based on clinical or/and imaging evidence.
• Arriving within 24h at hospital since last proof of good health.

Exclusion criteria

• no available data for 3 months modified Rankin Score
• modified Rankin Score≥3 prior the event

Trial design

2,000 participants in 15 patient groups

ASTRAL

Treatment:

Diagnostic Test: ASTRAL prognostic score

Basel cohort

Treatment:

Diagnostic Test: ASTRAL prognostic score

Berlin cohort

Treatment:

Diagnostic Test: ASTRAL prognostic score

Bern Cohort

Treatment:

Diagnostic Test: ASTRAL prognostic score

Bologna cohort

Treatment:

Diagnostic Test: ASTRAL prognostic score

Dijon cohort

Treatment:

Diagnostic Test: ASTRAL prognostic score

Lisbon cohort

Treatment:

Diagnostic Test: ASTRAL prognostic score

Israel cohort

Treatment:

Diagnostic Test: ASTRAL prognostic score

Innsbruck cohort

Treatment:

Diagnostic Test: ASTRAL prognostic score

St. Gallen cohort

Treatment:

Diagnostic Test: ASTRAL prognostic score

Lugano cohort

Treatment:

Diagnostic Test: ASTRAL prognostic score

Chicago cohort

Treatment:

Diagnostic Test: ASTRAL prognostic score

West Virginia cohort

Treatment:

Diagnostic Test: ASTRAL prognostic score

Zurich cohort

Treatment:

Diagnostic Test: ASTRAL prognostic score

Seoul cohort

Treatment:

Diagnostic Test: ASTRAL prognostic score