Posterior Circulation Clot Burden Score (Pc-CBS) Predicts Clinical Outcome After Acute Ischemic Stroke Related to Posterior Circulation Occlusions : An Externally Validated Radiological Score (PC-CBS)

Vaud University Hospital Center

Status: Completed

Conditions: Posterior Circulation Brain Infarction; Arterial Occlusion Disease; Acute Ischemic Stroke

Treatments: Diagnostic Test: Assessment of cervico-cerebral arterial occlusion pattern

Study type: Observational

Funder types: Other

Identifiers

NCT07122934

PC-CBS

Details and patient eligibility

About

Posterior circulation strokes (PCS) represent ~30% of all ischemic strokes, but existing prognostic tools are limited, especially for non-basilar artery occlusions. Accurate early outcome prediction may aid treatment decisions and clinical trial design. We developed and externally validated the Posterior Circulation Clot Burden Score (PC-CBS), a radiological tool to predict 3-month functional outcome in acute ischemic stroke due to posterior circulation occlusion.

Enrollment: 1,828 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age >18 years old
• admitted within 24h from last known well
• symptomatic arterial occlusion. The following arterial occlusions were eligible for inclusion: the extracranial vertebral artery between the V0 and V3 segments; the intracranial portion of the vertebral artery; the basilar artery either in its proximal, mid and/or distal segment, the P1 and/or the P2 segments of the posterior cerebral artery.

Exclusion criteria

• simultaneous clinical and/or radiological strokes in the posterior and anterior circulation

Trial design

1,828 participants in 2 patient groups

Development and Internal validation cohort

Treatment:

Diagnostic Test: Assessment of cervico-cerebral arterial occlusion pattern

External validation cohort

Treatment:

Diagnostic Test: Assessment of cervico-cerebral arterial occlusion pattern