Posterior Macular Adhesion: A Potential Risk Factor for Non-exudative Age Related Macular Degeneration (AMD) to Develop Exudative AMD (PAM)

The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery

Status: Unknown

Conditions: Detachment of the Posterior Hyaloid; Dry Age-related Macular Degeneration

Treatments: Device: ultrasound; Device: OCT

Study type: Observational

Funder types: Other

Identifiers

NCT00926861

09-052-0409

Details and patient eligibility

About

Choroidal neovascularisation in age related macular degeneration is one of the major causes of legal blindness in the western world existing in two major occurences, the dry and the wet form.The etiology of age related macular degeneration is yet unknown. Genetic factors, oxidative stress, Ischaemia, and aging of the retinal pigment epithelium are discussed as etiologic factors. The risk of rapid vision loss is much higher in wet AMD, a dry form may transform to a wet form. From a prior study the investigators know that the posterior hyaloid is significantly more frequent attached in wet AMD. This study is conducted to examine whether the attached posterior hyaloid is a risk factor to develop wet AMD in dry AMD cases.

Enrollment: 320 estimated patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Dry MD
• Age over 50 years

Exclusion criteria

• Macular pathologies other than age related macular degeneration (like diabetic maculopathy, macular pucker, macular hole)
• Prior vitrectomy or buckle surgery
• Uveitis posterior, multifocal chorioiditis
• Pathologic myopia
• Diabetic retinopathy
• Visualization of the macula not possible (dens cataract, vitreous haemorrhage)

Trial design

320 participants in 1 patient group

Dry AMD

Description:

male or female persons aged over 50 years with dry age-related macular degeneration

Treatment:

Device: ultrasound

Device: OCT