Posterior Nasal Nerve Neurectomy for Treatment of Intractable Allergic Rhinitis

Kafrelsheikh University

Status: Not yet enrolling

Conditions: Intractable Allergic Rhinitis

Treatments: Device: Posterior Nasal Nerve neurectomy

Study type: Interventional

Funder types: Other

Identifiers

NCT06887842

KFSIRB200-543

Details and patient eligibility

About

This study aims to compare the outcomes of posterior nasal nerve neurectomy in patients with resistant Allergic rhinitis by using three different methods ( surgical resection vs radiofrequency ablation vs surface coblation ) through assesment of functional outcomes, postoperative complications, and impacts on quality of life.

Enrollment: 84 estimated patients

Sex: All

Ages: 16 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged 16 to 65 years, fit for surgery, diagnosed as moderate to severe persistent Allergic Rhinitis, as per the ARIA guidelines having 3 or more of the typical symptoms of Allergic Rhinitis including nasal discharge, repeated attacks of sneezing, nasal itching and nasal obstruction.

Exclusion criteria

• • Patients with Coexisting nasal pathologies that could influence the outcomes of the surgery like: chronic granulomatous diseases of the nose, nasal tumors, chronic sinsitis with or without nasal polyps, etc.

  • Patients who had used topical steroid nasal spray, oral or topical antihistamines, oral leukotriene antagonists, oral or tobical nasal decongestants in the last 2 weeks.
  • Immunocompromised patients, Systemic disease affecting prognosis such as diabetes mellitus, hypertension,chronic liver failure or heart failure.
  • Unwillingness for endoscopic surgery.
  • Patients younger than 18 years of age.
  • Patients who are unfit for general anesthesia.
  • Previous history of nasal surgery

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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84 participants in 3 patient groups

Posterior nasal neurectomy by surgical resection

Active Comparator group

Treatment:

Device: Posterior Nasal Nerve neurectomy

Device: Posterior Nasal Nerve neurectomy

Device: Posterior Nasal Nerve neurectomy

Posterior nasal neurectomy by radio- frequency ablation

Active Comparator group

Treatment:

Device: Posterior Nasal Nerve neurectomy

Device: Posterior Nasal Nerve neurectomy

Device: Posterior Nasal Nerve neurectomy

Surface coblation on area of the course of the Posterior nasal nerve

Active Comparator group

Treatment:

Device: Posterior Nasal Nerve neurectomy

Device: Posterior Nasal Nerve neurectomy

Device: Posterior Nasal Nerve neurectomy