Postoperative Adjuvant TACE Treatment in CK18 Positive Patients

Naval Military Medical University (Second Military Medical University)

Status: Completed

Conditions: Postoperative Adjuvant TACE; Hepatocellular Carcinoma.

Study type: Observational

Funder types: Other

Identifiers

NCT02724345

ZD201206002-P1

Details and patient eligibility

About

To evaluate and analyse the clinical effect and application value of postoperative adjuvant TACE treatment in patients with different expression levels of CK18 using randomized controlled study and provide evidence for the necessity of postoperative adjuvant TACE.

Enrollment: 320 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Via clinical diagnosis and confirm it is primary liver cancer
2. Pathological evidence of HCC
3. Estimate tumor can gain treatment of curing operation
4. No evidence for extrahepatic metestasis
5. liver function ：Child-Pugh A/B

Exclusion criteria

1. reject to attend；
2. impossible to come to our hospital for physical examination regularly.
3. cancer epitome、seed focus、lymph node or distant metastasis
4. Blood clotting function hindrance; 5, Patients with other diseases which may affect the treatment mentioned.

Trial design

320 participants in 2 patient groups

CK18 positive

Description:

HCC patients with CK18 high expression levels in tumor tissue.

CK18 negative

Description:

HCC patients with CK18 high expression levels in tumor tissue.