Postoperative Analgesia in Patients Undergoing Percutaneous Nephrolithotomy

Ain Shams University

Status: Completed

Conditions: Postoperative Analgesia

Treatments: Drug: Intravenous lidocaine infusion; Other: Erector spinae plane block (ESPB); Other: Intravenous infusion of normal saline; Other: ESPB with normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT06078241

FMASU MS 556/ 2023

Details and patient eligibility

About

Percutaneous nephrolithotomy (PCNL) is a minimally invasive procedure to remove stones from the kidney by a small puncture wound through the skin. Patients receiving lidocaine infusion had lower pain scores, reduced postoperative analgesic requirements and decreased intraoperative anesthetic requirements. Erector spinae plane block (ESPB) seems to be effective when compared with no block or a placebo block.

Enrollment: 150 patients

Sex: All

Ages: 21 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) score I-II..
• Body mass index < 35 kg/m2.

Exclusion criteria

• Patient's refusal.
• Known coagulopathy.
• Known peripheral neuropathy or neurological deficits.
• Chronic pain disorders.
• Known allergy to study drugs

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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150 participants in 3 patient groups, including a placebo group

Intravenous lidocaine infusion

Active Comparator group

Treatment:

Drug: Intravenous lidocaine infusion

Erector spinae plane block (ESPB)

Active Comparator group

Treatment:

Other: Erector spinae plane block (ESPB)

Intravenous infusion of normal saline and ESPB with normal saline

Placebo Comparator group

Treatment:

Other: ESPB with normal saline

Other: Intravenous infusion of normal saline