Postoperative Analgesia of Quadratus Lumborum Block Versus Epidural Block After Major Abdominal Surgeries

Mansoura University

Status: Completed

Conditions: Elective Major Abdominal Surgery

Treatments: Other: Ultrasound-guided bilateral quadratus lumborum block; Other: Thoracic epidural block; Drug: Maintenance of general anaesthesia; Drug: Induction of general anaesthesia with propofol; Drug: Muscle Relaxant

Study type: Interventional

Funder types: Other

Identifiers

NCT04541732

MS ∕18.06.187

Details and patient eligibility

About

Acute postoperative pain is an important issue after major abdominal surgeries for which different analgesic modalities have been tried.

Epidural analgesia is the recommended technique to relieve pain after major abdominal surgeries owing to the proved superior analgesia, reduction of opioid-related side effects as nausea, vomiting, pruritis and sedation, earlier recovery of bowel function and earlier ability for postoperative mobility. However, it is not without complications.

Quadratus lumborum block is an ultrasound-guided block that provides patients with both visceral and somatic blockade. It lessens the potential risks associated with neuraxial techniques, so it may represent a novel alternative approach for analgesia after major abdominal surgeries.

Full description

The aim of this study is to detect the feasibility of ultra-sound guided bilateral quadratus lumborum block as a postoperative analgesic modality after major abdominal surgery in comparison to epidural block and its effects on total rescue analgesic requirements in the 1st postoperative 24hours, time to first analgesic request, pain VAS scores, intraoperative and postoperative hemodynamics and postoperative opioid-related side effects.

Under complete aseptic conditions, the patients will receive either thoracic epidural block or bilateral ultrasound-guided quadratus lumborum block after induction of general anaesthesia

Enrollment: 80 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) physical status I-III

Exclusion criteria

• Patient's refusal
• Significant cardiac, disease.
• Significant hepatic disease.
• Significant renal disease (serum creatinine ˃ 1.5 mg/dl).
• Patients with drug abuse
• Allergy to study medications
• Mental disease
• Communication barrier.
• Coagulopathy.
• Local skin infection

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 2 patient groups

Thoracic epidural block

Experimental group

Description:

Patients will receive thoracic epidural block following induction of general anaesthesia

Treatment:

Drug: Muscle Relaxant

Drug: Induction of general anaesthesia with propofol

Other: Thoracic epidural block

Drug: Maintenance of general anaesthesia

Bilateral quadratus lumborum block

Active Comparator group

Description:

Patients will receive Ultrasound-guided bilateral quadratus lumborum block following induction of general anaesthesia

Treatment:

Drug: Muscle Relaxant

Drug: Induction of general anaesthesia with propofol

Other: Ultrasound-guided bilateral quadratus lumborum block

Drug: Maintenance of general anaesthesia