Postoperative Analgesic Effect of Nefopam

Seoul National University

Status: Completed

Conditions: Stomach Neoplasms

Treatments: Drug: Saline; Drug: Nefopam

Study type: Interventional

Funder types: Other

Identifiers

NCT02561494

Nefo_stomach op

Details and patient eligibility

About

Nefopam will be administered to the patients undergoing laparoscopic gastrectomy under the total intravenous anesthesia (TIVA).

The investigators will evaluate whether the nefopam can decrease the total amount of remifentanil administered during the operation, which will reduce the acute opioid tolerance and following consumption of fentanyl during postoperative period.

Enrollment: 78 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Early or advanced gastric cancer

Exclusion criteria

• Refusal
• Use of preoperative analgesic drugs
• Pregnancy
• Recurred gastric cancer
• Seizure
• Cardiac disease
• Monoamine oxidase inhibitor
• Urologic disease
• Previous intrabdominal surgery
• Body mass index > 30 or < 16

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

78 participants in 2 patient groups, including a placebo group

Control

Placebo Comparator group

Description:

Intravenous normal saline 2 ml is given slowly as a placebo before the anesthesia induction and after finishing anesthesia.

Treatment:

Drug: Saline

Nefopam

Experimental group

Description:

Intravenous nefopam 20 mg is given slowly before the anesthesia induction and after finishing anesthesia.

Treatment:

Drug: Nefopam