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Postoperative Analgesic Effects of Dexmedetomidine for Transversus Abdominis Plane Block (TAP)

T

TC Erciyes University

Status and phase

Completed
Phase 4

Conditions

Pain

Treatments

Drug: Bupivacaine
Drug: Dexmedetomidine
Drug: serum physiologic

Study type

Interventional

Funder types

Other

Identifiers

NCT02064530
2014/37

Details and patient eligibility

About

the aim of this study is evaluate postoperative analgesic effects of dexmedetomidine added to bupivacaine on TAP block in patients undergoing lower abdominal surgery.

Full description

TAP block is being used a method of multimodal balanced analgesia reduces postoperative pain, opioid requirement after surgery and adverse effect of opioid such as sedation, nausea vomiting and ileus. Dexmedetomidine ,an alfa-2 adrenoreceptor agonist, is being used and adjuvant capable of prolonging duration of sensory and motor block on nerve blocks.

Enrollment

90 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • ASA 1-2
  • 18-65 aged
  • patient undergoing lower abdominal surgery

Exclusion criteria

  • chronic opioid consumption
  • bupivacaine and dexmedetomidine allergies
  • coagulopathy
  • infection at the needle insertion side
  • chronic liver and kidney disease

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

90 participants in 3 patient groups

bupivacaine
Active Comparator group
Description:
0,5% 20 ml bupivacaine added 0.9% 1 ml serum physiologic on TAP block
Treatment:
Drug: Bupivacaine
dexmedetomidine
Active Comparator group
Description:
100 mcg dexmedetomidine added to 0,5% 20 ml bupivacaine on TAP block
Treatment:
Drug: Dexmedetomidine
serum phsyologic
Sham Comparator group
Description:
0,9% 21 ml serum physiologic
Treatment:
Drug: serum physiologic

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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