Postoperative Analgesic Effects of Dexmedetomidine for Transversus Abdominis Plane Block (TAP)

TC Erciyes University

Status and phase: Completed; Phase 4

Conditions: Pain

Treatments: Drug: Bupivacaine; Drug: Dexmedetomidine; Drug: serum physiologic

Study type: Interventional

Funder types: Other

Identifiers

NCT02064530

2014/37

Details and patient eligibility

About

the aim of this study is evaluate postoperative analgesic effects of dexmedetomidine added to bupivacaine on TAP block in patients undergoing lower abdominal surgery.

Full description

TAP block is being used a method of multimodal balanced analgesia reduces postoperative pain, opioid requirement after surgery and adverse effect of opioid such as sedation, nausea vomiting and ileus. Dexmedetomidine ,an alfa-2 adrenoreceptor agonist, is being used and adjuvant capable of prolonging duration of sensory and motor block on nerve blocks.

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA 1-2
• 18-65 aged
• patient undergoing lower abdominal surgery

Exclusion criteria

• chronic opioid consumption
• bupivacaine and dexmedetomidine allergies
• coagulopathy
• infection at the needle insertion side
• chronic liver and kidney disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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90 participants in 3 patient groups

bupivacaine

Active Comparator group

Description:

0,5% 20 ml bupivacaine added 0.9% 1 ml serum physiologic on TAP block

Treatment:

Drug: Bupivacaine

dexmedetomidine

Active Comparator group

Description:

100 mcg dexmedetomidine added to 0,5% 20 ml bupivacaine on TAP block

Treatment:

Drug: Dexmedetomidine

serum phsyologic

Sham Comparator group

Description:

0,9% 21 ml serum physiologic

Treatment:

Drug: serum physiologic