Postoperative Analgesic Effects of Using Dexmedetomidine for Ultrasound Guided Thoracic Paravertebral Block

TC Erciyes University

Status and phase: Completed; Phase 4

Conditions: Pain

Treatments: Drug: bupivacaine; Drug: dexmedetomidin; Drug: serum physiologic

Study type: Interventional

Funder types: Other

Identifiers

NCT02544893

2014/649

Details and patient eligibility

About

we aimed postoperative analgesic effects of using bupivacaine alone or added dexmedetomidine for ultrasound guided thoracic paravertebral block in thoracotomy

Full description

paravertebral block is commonly used in the treatment for acute and chronic pain.The duration of paravertebral block could theoretically be prolonged with neurolytic agents. Dexmedetomidine ,an alfa-2 adrenoreceptor agonist, is being used and adjuvant capable of prolonging duration of sensory and motor block on nerve blocks.

Enrollment: 93 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA 1-2
• 18-65 aged
• patient undergoing thoracotomy

Exclusion criteria

• chronic opioid consumption
• bupivacaine and dexmedetomidine allergies
• coagulopathy
• infection at the needle insertion side
• chronic liver and kidney disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

---

93 participants in 3 patient groups

bupivacaine

Active Comparator group

Description:

0,5% 20 ml bupivacaine added 0.9% 1 ml serum physiologic on paravertebral block

Treatment:

Drug: bupivacaine

dexmedetomidine

Active Comparator group

Description:

100 mcg dexmedetomidine added to 0,5% 20 ml bupivacaine on paravertebral block

Treatment:

Drug: dexmedetomidin

serum phsyologic

Active Comparator group

Description:

0,9% 21 ml serum physiologic

Treatment:

Drug: serum physiologic