Postoperative Assessment of Platelet-Rich Plasma and Platelet-Rich Fibrin in Temporomandibular Joint Surgery

Jingping Wang, MD, Ph.D.

Status: Not yet enrolling

Conditions: Temporomandibular Joint Disorders

Study type: Observational

Funder types: Other

Identifiers

NCT07359131

2024P003298

Details and patient eligibility

About

The goal of this observational study is to evaluate postoperative outcomes following temporomandibular joint (TMJ) surgery and to compare the effectiveness of intraoperative platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) injections in patients with temporomandibular joint disorders.

The study includes adult patients who underwent TMJ surgery and received either PRP or PRF intraoperatively. The main questions this study aims to answer are:

Whether intraoperative PRP or PRF injection is associated with differences in postoperative pain intensity and recovery.

Whether PRP and PRF differ in their effects on postoperative jaw function, including maximum mouth opening and joint symptoms.

If there is a comparison group: Researchers will compare patients who received intraoperative PRP with those who received intraoperative PRF to assess differences in postoperative pain, functional outcomes, and joint-related symptoms.

Participants will:

Have their existing medical records reviewed retrospectively.

Provide postoperative outcome data derived from routine clinical follow-up, with no prospective recruitment or intervention.

Enrollment: 700 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients aged 18 to 75 years (inclusive)

Underwent unilateral or bilateral temporomandibular joint (TMJ) arthroscopy

Received intraoperative platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) injection during TMJ arthroscopy

Exclusion criteria

Age younger than 18 years or older than 75 years

Did not undergo TMJ arthroscopy

Did not receive intraoperative PRP or PRF injection

Incomplete clinical or follow-up data

Trial design

700 participants in 3 patient groups

Group 1 - Platelet-Rich Plasma injection therapy group

Description:

Patients who received Platelet-Rich Plasma injections during surgery.

Group 2 - Platelet-Rich Fibrin injection therapy group

Description:

Patients who are receiving Platelet-Rich Fibrin injections during surgery.

Group 3 - non injection therapy group

Description:

Patients who are not receiving Platelet-Rich Plasma nor Platelet-Rich Fibrin injections during surgery.