Postoperative Cesarean Delivery Pain Relief; Diclofenac Versus Bupivacaine

Rajavithi Hospital

Status and phase: Completed; Phase 4

Conditions: Cesarean Delivery

Treatments: Drug: Bupivacaine; Drug: Diclofenac

Study type: Interventional

Funder types: Other

Identifiers

NCT03039426

RJBUPI

Details and patient eligibility

About

This randomized controlled trial, compared postoperative pain score in patient undergoing cesarean delivery between bupivacaine peritoneal and subcutaneous infiltration and diclofenac intramuscular injection

Full description

Postoperative cesarean delivery was painful that can effect daily activity, resulted in poor quality of life and required morphine injection to relief pain which had both maternal and breastfeeding infancy side effect. So this study compare efficacy of diclofenac and bupivacaine by measured the pain score and requirement of morphine injection.

Enrollment: 120 patients

Sex: Female

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients undergo elective or urgency cesarean delivery at Rajavithi Hospital in 2016-2017

  • Urgency conditions: CPD, fail induction of labor, antepartum hemorrhage without hypovolemic shock, dystocia, previous cesarean section and active labor, malpresentation in labor, macrosomic presentation in labor

• Pregnant women more than 20 years of age

• Gestational age more than 37 week

• Cesarean section under regional or general anesthesia

• Ability to communicating, writing and reading Thai language

Exclusion criteria

• Inability to communicating or writing or reading Thai language
• Contraindicated to bupivacaine or diclofenac or morphine
• Pregnant women with emergency conditions
• Have one or more complication of pregnancy
• Intraoperative arrhythmia
• Pregnant women less than 20 years of age
• Regional anesthesia with morphine

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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120 participants in 2 patient groups

Group Bupivacaine

Experimental group

Description:

0.5% bupivacaine 20ml divided in two; 10 ml intraperitoneal infiltration and 10 ml subcutaneous infiltration

Treatment:

Drug: Bupivacaine

Group Diclofenac

Active Comparator group

Description:

diclofenac 75 mg intramuscular, 2 hours postoperation

Treatment:

Drug: Diclofenac