Postoperative Cognitive Dysfunction After Propofol Anesthesia for Noncardiac Surgery (POCD ELA)

Centre Hospitalier Universitaire de Besancon

Status: Unknown

Conditions: Patients ASA I, II, III

Treatments: Procedure: neuropsychological test battery

Study type: Interventional

Funder types: Other

Identifiers

NCT02841423

API/2013/44

Details and patient eligibility

About

Background: Postoperative cognitive dysfunction (POCD) in elderly patients after noncardiac surgery is a common problem.

Therefore,this study was designed to assess POCD after closed-loop coadministration of propofol and remifentanil guided by bispectral index in comparison to intravenous anesthesia in elderly patients undergoing major noncardiac surgery. Methods: After approval of the local ethical committee was obtained, 204 patients (American Society of Anesthesiologists physical status I-III; age, > 55 yr) undergoing surgery (duration, > 1 h) were enrolled into this pospective randomized monocenter study. Patients received anesthesia 3 days after using a neuropsychological test battery.

Enrollment: 204 estimated patients

Sex: All

Ages: 55+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists physical status I-III;
• undergoing surgery (duration, > 1 h)

Exclusion criteria

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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204 participants in 2 patient groups

INTRAVENOUS ANESTHESIA

Experimental group

Description:

neuropsychological test battery

Treatment:

Procedure: neuropsychological test battery

CLOSED LOOP ANESTHESIA

Experimental group

Description:

neuropsychological test battery

Treatment:

Procedure: neuropsychological test battery