Postoperative Cognitive Dysfunction in Elderly Urologic Oncology Patients (POCD)

Istanbul University

Status: Unknown

Conditions: Frailty; Postoperative Delirium; Postoperative Cognitive Dysfunction

Treatments: Diagnostic Test: Confusion Assessment Method; Diagnostic Test: Addenbrooke Cognitive Examination III (ACE-III); Device: Near Infrared Spectroscopy (NIRS); Diagnostic Test: Blood sample

Study type: Observational

Funder types: Other

Identifiers

NCT04837391

2019/1555

Details and patient eligibility

About

Postoperative cognitive changes are more common in elderly patients, which can result in poor quality of life, loss of workforce, disability, early retirement, physical-social dependence, increased health care cost and premature mortality. Postoperative cognitive complications are also quite common in extensive oncological surgeries. In this study, our aim is to evaluate the relationship between the development of postoperative cognitive dysfunction (POCD) in geriatric urologic oncology patients with brain injury and inflammatory markers [S100 β, neuron specific enolase (NSE), interleukin 6 (IL-6) and high mobility group box-1 (HMGB-1 protein)].

Full description

The incidence of POCD changes by age group, type of surgery, testing neuropsychological tests, timing of tests, and the method used for diagnosis. In non-cardiac surgery over the age of 60; the incidence of POCD was 26% in the postoperative 1st week and 10% in the postoperative 3rd month. Although old age is an important risk factor, POCD incidence of up to 36.6% has been reported in a younger period. Major cancer surgery is an important risk factor for development of POCD.

Numerous biomarkers such as; S100β, NSE, Human IL-6, HMGB-1 protein; have been evaluated in studies to determine the diagnosis, prognosis, stage and treatment of POCD.

In this study, our aim is to evaluate the relationship between the development of postoperative cognitive dysfunction (POCD) in geriatric urologic oncology patients with brain injury and inflammatory markers. (S100β, NSE, Human IL-6 and HMGB-1 protein).The hypothesis of our study is that postoperative brain injury and inflammatory markers (S100β, NSE, Human IL-6 and HMGB-1 protein) will be higher in patients who develop POCD compared to patients who do not develop POCD in geriatric urologic oncology surgery.

Enrollment: 48 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients over the age of 65 who are planned to undergo major urooncological surgery.

Exclusion criteria

• Patients who refuse to participate in the study.
• Patients with severe hearing-vision problems.
• Patients with serious neurological-psychiatric disorders.
• Patients with language barrier.
• Patients with missing in any interventions.
• Patients with blood samples that are not suitable for the ELISA.

Trial design

48 participants in 1 patient group

Urologic oncology surgery in elderly

Description:

Elective urologic oncology surgeries such as radical nephrectomy, radical cystectomy, radical prostatectomy in older than 65 years

Treatment:

Diagnostic Test: Blood sample

Diagnostic Test: Addenbrooke Cognitive Examination III (ACE-III)

Device: Near Infrared Spectroscopy (NIRS)

Diagnostic Test: Confusion Assessment Method