Postoperative Cognitive Dysfunction in Geriatric Patients

University Hospital Basel

Status: Completed

Conditions: Postoperative Complications; Memory Disorders; Delirium, Dementia, Amnestic, Cognitive Disorders

Study type: Observational

Funder types: Other

Identifiers

NCT00512200

EK 75/07

Details and patient eligibility

About

Geriatric patients have a high risk of developing postoperative cognitive deficits. Hypothetical causes are insufficient intraoperative cerebral perfusion or drugs that are administered in the perioperative setting. This study will investigate the role of these two factors in patients aged 65 or older undergoing elective surgical procedures under general aesthesia. Non-invasive techniques will be used to monitor intraoperative cerebral perfusion and anticholinergic activity in the patient's blood is determined. Data will be compared to those of a young (20-40 year old) group of patients undergoing elective surgical procedures using an identical anesthetic technique. A second control group of healthy volunteers older than 65 will be investigated to quantify practice effects with repeated testing of cognitive functions.

Enrollment: 280 patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Elective surgical procedure under general anaesthesia

Exclusion criteria

• History of cerebrovascular disease
• Mini Mental status <23
• Cardiac surgery
• Neurosurgery

Trial design

280 participants in 3 patient groups

Case

Description:

Patients aged 65 or older

Control

Description:

Patients aged 20 to 40

Control 2

Description:

Healthy volunteers aged 65 or older