Postoperative Cognitive Function and EEG (POEM)

Air Force Military Medical University of People's Liberation Army

Status: Enrolling

Conditions: Aging; EEG With Periodic Abnormalities; Postoperative Cognitive Dysfunction

Treatments: Other: EEG(Electroencephalogram) change

Study type: Observational

Funder types: Other

Identifiers

NCT04219033

XJH-A-20190726

Details and patient eligibility

About

In the elderly patients undergoing elective non-cardiac major surgery, the differences of EEG parameters between those with and without postoperative cognitive dysfunction were observed to determine the characteristic changes of EEG parameters related to postoperative cognitive dysfunction

Enrollment: 1,250 estimated patients

Sex: All

Ages: 65 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. aged 65 and above
2. non-cardiac surgery under general anesthesia;
3. American Society of Anesthesiology(ASA) classification I- II
4. Patients aged 18-40 years old are set as background

Exclusion criteria

1. patients with central nervous system diseases and mental diseases
2. preoperative minimal mental status examination(MMSE) score<24;
3. ASA status III or higher

3. those who have received less than 5 years of education since entering primary school; 4) history of sedatives or antidepressants use; 5) existed or anticipated alcohol or drug abuse(over 40°c and over 100ml per day for the past 3 months); 6) history of surgery within the previous year; 7) those with severe visual or hearing impairment; 8) those participated in other clinical studies within last 3 months;

Trial design

1,250 participants in 2 patient groups

with postoperative cognitive dysfunction

Treatment:

Other: EEG(Electroencephalogram) change

without postoperative dysfunction

Treatment:

Other: EEG(Electroencephalogram) change