Postoperative Dexmedetomidine in Prevention of Postoperative Delirium

Shenzhen United Scheme Technology

Status: Completed

Conditions: Anesthesia; Adverse Effect; Delirium in Old Age

Treatments: Drug: Dexmedetomidine injection; Drug: Sufentanil injection

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT06382961

SZUS_231101

Details and patient eligibility

About

The goal of this clinical trial is to learn how postoperative infusion of dexmedetomidine would influence postoperative delirium in elderly patients undergoing lung surgery. The main questions it aims to answer are :

1. Does postoperative dexmedetomidine reduce the incidence of delirium after lung surgery?
2. Does postoperative dexmedetomidine introduce other medical problems? Researchers will compare dexmedetomidine and sufentanil to see if dexmedetomidine works to reduce delirium.

Participants will undergo routine postoperative care:

1. Patient-controlled self anesthesia with sufentanil only or combination of sufentanil and dexmedetomidine
2. Postoperative visit twice a day for at least seven days

Enrollment: 287 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• elective surgery for lobectomy or segmentectomy

Exclusion criteria

• local allergy to anesthetics;
• patients with a clear preoperative history of nervous system and mental system diseases or long-term use of sedatives or antidepressants;
• history of alcoholism, drug abuse or drug dependence;
• have a history of brain surgery or injury;
• epilepsy and associated mental and cognitive dysfunction, long-term stress stimulation, or psychological disorders;
• sick sinus syndrome, second-degree or greater atrioventricular block or other contraindications for use of α2 adrenergic agonist;
• liver and kidney insufficiency.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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287 participants in 2 patient groups

Experiment

Experimental group

Treatment:

Drug: Dexmedetomidine injection

Control

Active Comparator group

Treatment:

Drug: Sufentanil injection